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 Plants & Other Toxins That Are Poison To Dogs

I have spent hundreds of hours over the past 20 years compiling and creating the health information shown on this page...and I'm always looking for more!  A lot of the information has been gathered from various poison control websites in order to present as complete a list as possible and links to other website pages are given whenever possible and I hope you find them helpful and easy to use.  I have a lot of people asking if they can copy this page...I prefer that you do not copy, transfer, or download the content of these pages onto another website because then I have no control over how up to date your copy would be.  If you wish to link to this page, please let me know so that I can send you the proper link information.  Having said that, I always welcome additional information to be added to the page, and feedback and comments are always welcome.  Thank you for your co-operation...I will happily share this information with anyone!  I hope that no one reading this page ever needs the information, but if you do, I hope this will be of some help!

The following is a list of plants and other toxins known to be poisonous to dogs (and cats too!).  In the case of plants some poisonous parts may only be the seeds or leaves or roots. In all cases, use extreme caution and keep your pets away from these plants. If you cannot supervise your pets in your garden, replant with safe non-toxic plants. As with most things there are a lot of other factors that contribute to the toxicity of the plants, age & size of the animal, how much of the plant they ingest, where the plant is in it's "growing" stage.  Also please read "Algae Toxicity Killing Dogs"...click on the link for a "word" download, or here for a pdf document (you must have Adobe Reader to open a pdf document).

Puppies, at least most of them, chew just about anything especially when they are teething and therefore are at far greater risk of poisoning. Also some dogs love to chew plants as well as the grasses they will chew for medicinal purposes, you must watch carefully to determine the habits of your particular pet!

Some of the toxic plants listed below will cause nothing more than a rash or itchiness but some will cause much more severe reactions (eg. swelling of the face and throat) just by your dog coming in contact with them. This can quickly become fatal depending on the amount of swelling…a quick trip to your vet is still the best idea if you see any swelling or know that your pet has ingested any of these plants.

Ascertaining the cause of poisoning is always very difficult so make sure that you take along stool &/or vomit samples for your vet and, if possible, the plant or pieces of it that the dog has ingested…try and find the leaves, twigs or berries that have been chewed. This could make a difference between life and death for your furfriend! Dogs usually will not chew on a toxic plant because they are not generally appealing but if you ever do have a dog poisoned by plants remove the plant from your property to prevent a repeat of the problem.

Ask your local veterinarian and/or nursery for more information. For plants with a number (ex. *3) beside them, please see the legend below for the most commonly known toxic effect. If you have anything, plants or otherwise, that you can add to this list, please send me an e-mail.

Also, please read our page Are you feeding your dog "Death In A Bag"? for more information about pet foods and the huge recall on hundreds of pet foods in early 2007.

Plants & other growing things:

Aconite

Alder Buckthorn

Alfalfa

Almond *4

Alocasia / Caladium

Aloe - A. Barbadensis

Alsike Clover

Amaryllis *4

American Elder

American Holly

American Mistletoe / Phoradendron

American Yew *4

Andromeda

Anemone

Angel's Trumpet

Apple seeds

Apricot *4

Arrowgrass

Arrowhead Vine *3

Asian Lily (Liliaceae)

Asparagus

Asparagus Fern *4

Astragalus

Australian Nut

Australian Umbrella Tree

Autumn Crocus / Colchicum autumnale

Avocado

Azalea   *4

Balsam

Balsam Pear *4

Baneberry

Baptisia

Bayonet

Beargrass

Belladonna

Be-Still-Tree

Bird Of Paradise *4

Bird Rape

Birdsfoot

Bittersweet / Celastrus

Bittersweet Woody *1

Black Cherry

Black Henbane

Black Locust *4

Black Nightshade

Black Oak

Black Walnut

Black-Eyed Susan

Bladder Pod

Bleeding Heart

Bloodroot

Blue Cardinalflower

Blue Cohosh

Blue Flag Iris

Bluebonnet

Blueweed

Bog-Laurel

Boston Ivy *3

Bouncing Bet

Boxwood

Bracken

Bracken Fern

Branching Ivy

Broad Beans

Brocolli (in large amounts)

Broom Snakeweed

Buckeyes (Horse Chestnuts) *4

Buckthorn

Buckwheat

Buddist Pine

Buffalo Bur

Bulbous Buttercup

Bur Buttercup

Burke's Lupine

Burning Bush

Buttercup *7

Cactus

Caladium/ Alocasia *3

Caley Pea

California Bluebell

California Rose-Bay

Calla Lily

Canada Nettle

Canada Yew

Canadian Milk-Vetch

Candelabra Aloe

Candelabra-Cactus

Caper Spurge

Cardinal Flower

Castor Bean *1

Celandine

Celery-Leaved Buttercup

Ceriman

Cherries (Most Forms) *4

Chinaberry *6

Chinese Evergreen

Chinese-Lantern

Chives

Chokecherry

Christmas Rose / Helleborus niger

Chrysanthemum *2

Clematis

Climbing Nightshade

Clover

Cockle Burr

Cockle Corn

Colorado Rubberweed

Comfrey

Cordatum

Coriaria *6

Corn

Corn Cockle

Corn Plant ~ Cornstalk Plant)

Corn Poppy

Cornflower

Corydalis

Cow Cockle

Cowbane

Cowslip

Creeping Charlie *4

Creeping Fig *2

Crocus

Crotalaria

Croton

Crowfoot

Crown Of Thorns / Euphorbia milii

Crown Vetch

Cycads

Cyclamen

Cypress Spurge

Daffodil *1

Daphne

Datura (Angel's Trumpets)

Deadly Nightshade

Death Angel Mushrooms

Death Camas

Death Cap Mushrooms

Delphinium *1

Destroying Angels

Devil's Ivy

Devil's Trumpet

Devil's-Backbone

Dicentra (Bleeding Heart)

Dieffenbachia / Dumb Cane

Dock

Dogbane

Doll's-Eyes

Dologeton

Downy Thornapple

Dracaena (all types)

Drooping Leucothoe

Drunk Cane *3

Dumb Cane

Dutchman's Breeches *7

Easter Lily

Eggplant

Elderberry

Elephant Ear *4

Emerald Duke *3

Emerald Feather

Emerald Fern

English Bluebell

English Holly *4

English Ivy

English Yew *4

Ergot

Euonymus Japonicus / Japanese Euonymus

European Buckthorn

European Elder

European Spindletree

Evergreen

Everlasting Pea

False Hellbore

False Morels

False Ragweed

February Daphne

Fern

Fiddleheads

Fiddleneck

Field Horsetail

Five-Hooked Bassia

Flamingo Lily

Flax

Florida Beauty

Fly Agaric

Fly Honeysuckle

Four O'clock

Foxglove *1

Fritillaria

Fruit Salad Plant

Fruit seeds &/or pits

Garden-Sorrel

Garland Daphne

Garlic (in larger doses)

Gas Plant

Geraniums

Giant Dumbcane

Giant Hogweed

Gill-Over-The-Ground

Glacier Ivy

Gladiolas

Glocal Ivy *4

Glory Lily

Golden Chain Tree

Golden Fowl

Golden Glow

Golden Pothos

Golden-Bean

Golden-Chain

Golden-Trumpet

Grapes & Raisins (all kinds) (click here for more info)

Grass Pea

Greasewood

Great Lobelia

Greater Celandine

Green Gold Nephthysis

Green Tansy Mustard

Ground Cherry *1

Ground Ivy

Groundsel

Guelder-Rose

Hairy Vetch

Halogeton

Heart Ivy *4

Heart-Leaved Philodendron

Heavenly Bamboo

Hellebo

Hellebore

Hemlock

Hemp Dogbane

Henbane

Holly

Honeysuckle

Hops

Horse Chestnut (Buckeye) *4

Horse Nettle

Horsebeans

Horsebrush

Horseradish

Horsetail

Hound's Tongue

Hurricane Plant

Hyacinth

Hydrangea

Iceland Poppy

Indian Mustard

Indian Poke

Indian Tobacco

Indian Turnip *1

Iris (All Kinds)

Irises

Ivy (All Kinds) / Hedera helix

Jack-In-The-Pulpit

Jack-O'lantern Fungus

Japanese Pieris

Japanese Plum *4

Japanese Wisteria

Japanese Yew

Jasmine *7

Java Beans

Jequirity Bean

Jerusalem Cherry / Solanum pseudocapsicum

Jessamine

Jimson Weed

Johnson Grass

Jonquil

Jungle Trumpets

Juniper

Kaffir Lily

Kalanchoe

Kentucky Coffee Tree

Klamath Weed

Kochia

Laburnum

Lace Fern

Lacy Tree

Lamb's Quarters

Lantana

Large-Leaved Lupine

Larkspur *1

Laurel

Leafy Spurge

Leatherwood Ligustrum / Japonicum'texanum Lily (Most Forms)

Lily-Of-The-Valley

Lobelia

Locoweed

Low Larkspur

Lucerne

Lupine *7

Macadamia (plant & nuts)

Madagascar Dragon Tree

Maidenhair Tree

Mandrake (May Apple) *7

Mango

Marble Queen

Marigold

Marijuana *5

Marsh Arrow-Grass

Marsh Horsetail

Marsh Marigold (Cowslip)

Matrimony Vine *7

Mayapple (Mandrake) *7

Menzies Larkspur

Mescal Bean *7

Mexican Breadfruit

Mexican Poppy

Milkweed

Milo

Mistletoe & Mistletoe Fig

Mock Orange *4

Monkey Agaric Mushrooms

Monkey Pod

Monkshood

Monstera

Moon Flower

Moonseed

Moonweed *6

Morning Glory *5

Mother-In-Law Plant

Motherwort

Mountain Fetterbush

Mountain Laurel

Mushrooms *7

Naked-Flowered Sneezeweed

Narcissus / Paperwhites & other winter forced bulbs

Narrow-Leaved Vetch

Nephthytis

Nettle

Nicotiana / Ornamental Tobacco Nightshade

Oak

Northern Water-Hemlock

Nutmeg *5

Nux Vomica

Oak (Leaves & Acorns)

Oats (growing oats, not processed)

Ohio Buckeye

Oleander

Onion

Osage-Orange

Oxalis

Panda

Panther

Panther Cap Mushrooms

Pathos *3

Pawpaw

Peach pits*4

Pear

Pencil Tree

Peony

Periwinkle *5

Peruvian Lily

Petty Spurge

Peyote *5

Philodendron *3

Pigweed

Pimpernal

Pin Cherry

Pink Lady's-Slipper

Plumosa Fern

Plums

Poinciana

Poinsettia / E. pulcherrima *2

Poison Hemlock *7

Poison Ivy

Poison Oak

Poison Suckleya

Poison Sumac

Poison Vetch

Pokeweed *1

Ponderosa Pine

Pop Mum *2

Poppy - all kinds

Pot Mum *4

Potato-skins or green potatos

Precatory Bean

Precatory-Pea

Prickly Comfrey

Prickly Lettuce

Primula

Privet *4

Prostrate Pigweed

Purple Cockle

Purple Locoweed

Purple Vetch

Pyracabtha

Queensland Nut

Radish

Ragwort

Rain Tree

Raisins / Grapes (all kinds) (click here for more info)

Rapeseed

Rattle Bush

Red Cedar

Red Chokecherry

Red Clover

Red Emerald

Red Maple

Red Oak

Red Princess *3

Red Sage

Redroot Pigweed

Reed Canarygrass

Rhododendron

Rhododendron Ficus

Rhubarb leaves *7

Ribbon Plant

Rosary Pea

Rubber Plant

Russian Knapweed

Sago Palm

Saint Johns Wort

Saskatoon (A serviceberry)

Satin Pothos

Scarlet Pimpernel

Schefflera

Scotch Broom

Seaside Arrow-Grass

Senecio

Sensitive Fern

Sheep Sorrel

Sheep-Laurel

Showy Lady's-Slipper

Showy Milkweed

Siberian Scilla

Sierra Laurel

Silky Lupine

Silvery Lupine

Singletary Pea

Skunk Cabbage *1

Small Lupine

Smooth Pigweed

Sneezeweed

Snowberry

Snowdrop

Snow-On-The-Mountain

Soapberry

Sorghum

Sour Dock (Sorrel)

Spatulate-Leaved Heliotrope

Spider Mum *2/4

Spinach

Spindletree Seeds

Spotted Dumbcane

Spotted Water-Hemlock

Sprangeri Fern

Spreading Dogbane

Spurge Laurel

Squirrel Corn

St. John's-Wort

Staggerweed

Star Of Bethlehem

Stinging Nettle

Stinking Rabbitbrush

Stinkweed

Sudan Grass

Sun Spurge

Sunflower

Sweet Clover

Sweetheart Ivy

Sweetpea

Swiss-Cheese Plant

Tall Larkspur

Tall Manna Grass

Tangier Pea

Tansy

Tansy Ragwort

Taro Vine

Tartarian Honeysuckle

Tea

Thin-Leaved Snowberry

Thistle Yew

Timber Milk Vetch

Toadstools

Tobacco

Tomato - leaves & stems

Tomato Vine *7

Tree Tobacco

Tree Vetch

Tree-Of-Heaven

Trefoil

Trillium

Tulip

Tung Oil

Tung Tree

Two-Grooved Milk-Vetch

Umbrella Plant *4

Veined Dock

Velvety Goldenrod

Vetch

Virginia Creeper

Walnuts

Water Hemlock *6

Weeping Fig *2

West Indian Lantana

Western Bleedingheart

Western Minniebush

Western Poison-Oak

Western Water-Hemlock

Western Yew *4

White Camas

White Clover

White Oak

White Rose-Bay

White Snakeroot

White Sweet-Clover

Wild Cabbage

Wild Call

Wild Calla

Wild False Indigo

Wild Ginger

Wild Indigo

Wild Mustard

Wild Onion

Wild Parsnip

Wild Radish

Wisteria *1

Wolfsbane

Wormseed Mustard

Yellow Iris

Yellow Jasmine

Yellow Lady's-Slipper

Yellow Rocket

Yellow Sage

Yellow Star

Yellow Star-Thistle

Yellow Sweet-Clover

Yellow Toadflax

Yesterday, Today, Tomorrow

Yew (Most Forms) *4

Yucca

 

 

LEGEND:
*1 Can cause diarrhea &/or vomiting
*2 Can cause irritation/rash if in contact with skin
*3 Can cause irritation/swelling in tongue and lips
*4 Can cause abdominal pain/cramps, diarrhea, &/or vomiting. Some of these plants can cause tumors, heart & respiratory &/or kidney problems.
*5 Hallucinogens
*6 Can cause convulsions
*7 Other toxic effects

OTHER COMMON ITEMS (INCLUDING COMMONLY USED HUMAN DRUGS) THAT ARE VERY TOXIC TO ANIMALS &/OR PROVEN TO CAUSE NEUROTOXICITY IN DOGS:

 

One of the worst killers of herding bred (also called collie-type) dogs is IVERMECTIN (also known as AVERMECTIN). Vets often tell people that Heartguard and/or Heartguard Plus are safe for Aussies, THEY ARE NOT!!!! We cannot stress often enough that these drugs have killed many Aussies. The only "safe" heartworm medication that we know of at this time is INTERCEPTOR. If you own horses, please be extremely careful when you worm them, don't let your Aussies near the area and make sure that any wormer spit out by your horse(s) is cleaned up. The "left-overs" can kill your dog!

 

Abamectin

Acanol

Acarexx

Ace

Acepro

Aceproject

Acepromazine (tranquilizer and pre-anesthetic agent)

Acetaminophen (Tylenol)

Acevet

ACP

Acqta

Adhesives

Adriamycin

Adriblastina

Advantage DUO

Alcohol

Algae toxins

Anti-Diarrheal Formula

Antifreeze

Aspirin in higher doses

Atopica

Atravet

Avermectin

Avocado

Batteries

Battery Acids

Bimectin

Bleach

BMD/Ivomec

Boric acid

Brake fluid

Butorphanol (analgesic and pre-anesthetic agent)

Caelyx

Carbon monoxide

Carburetor cleaner

Chocolate (all forms of chocolate)

Cicloral

Ciclosporin

Cigarettes & cigars

Citomid Citronella candles Cleaning fluid
Cocoa mulch

Coffee grounds & beans

Compost piles

Cosmetics Cryoperacid

Cyclosporine

Dental floss

Deodorants

Deodorizers

Deroser

Detergent

Diahalt

Diamode

Diarr-Eze

Diarrhea Relief

Digibind

Digitalis

Digoxin

Disinfectants

Dolorex

Doxil

Doxolem

Doxorubicin (chemotherapy agent)

Doxotec

Drain Cleaners

Dye

Ecomectin

Equell

Equimax

Equimectrin

Eqvalan

Fire extinguisher fluid

Fireworks

Fungicides

Furniture polish

Garden Fertilizer

Gasoline

Gasoline

Gengraf

Hair coloring

Heartguard

Herbicides

Household cleaners

Human medications: diet pills, etc.

Hurplex

Hydroxydaunomycin

Hydroxydoxorubicin

Hydroxyldaunorubicin

Ibuprofen (Advil)

Immodium

Immulem

Imogen

Imperim

Insecticides & pest baits: (i.e. strychnine, warfarin and others)

Isopropyl alcohol

Ivercare

Ivercide

Iverhart

Ivermectin (antiparasitic agent)

Iver-On

Iversol

Ivexterm

Ivomec

Kao-Paverin

Kerosene

Lanoxicaps

Lanoxin

Lawn & garden chemicals & fertizilers

Laxatives / Antidiarrheal meds containing Loperamide (Immodium)

Lead

Lemblastine

Leurocristine

Lighter fluid

Lighter fluid

Lomotil

Lop

Loperacap

Loperamide (ImodiumTM; antidiarrheal agent)

Lye

Mapluxin

Matches

Mectizan

Megamectin

Metal polish

Milbemycin (antaparasitic agent) Mineral spirits Modusik-A

Mothballs

Motor oil

Mouldy/spoiled foods

Moxidectin (antaparasitic agent)

Myocet

Nail polish & polish remover

Neoral

Nodiamex

Noromectin

Oncovin

Onions / onion powder

Optimmune

Oven cleaner

Oxicina

Paint

Paint remover

Paint thinner

Panomec

Pennies (post-1982 in particular because of zinc content

Permanent-wave lotion

Permidal

Petroleum Products: gasoline, motor oil, paint, paint thinner, lighter fluid

Phenol Phoenectin

Photographic developer

Potpourris - liquid or dry

Pramidal

Primectin

Privermectin

PromAce
Rat poison

Raxamida

Rediarin

Restasis

Rubber bands

Rubbing alcohol

Rubex

Salt

Sandimmune

SangCya

Selamectin (antaparasitic agent)

Shoe polish

Sleeping pills Snail or slug bait Soap
Soda pop

Some snakes, insects and toads

SparMectin

Stadol

String

Stromectol

Strychnine

Suntan lotion

Supremunn

Tar

Tea

Tobacco

Toilet bowl cleaner/deodorizers

Top-Dal

Torbugesic

Torbutrol

Torphajet

Toys with removable parts, hard eyes, noses, etc.

Tri-Heart

Turpentine

Unimectrin

Valfam

Velban

Velbe

Vinblastine (chemotherapy agent)

Vinblax

Vincasar

Vincrex

Vincristine (chemotherapy agent)

Vintec

Virbamec

Warfarin

Weed killers

Windshield-washer fluid

Wood preservatives

Xylitol (artificial sweetener)

Yarn

Yeast / yeast dough

Zimecterin

 

 

DRUGS SUSPECTED TO CAUSE NEUROTOXICITY IN DOGS (RESEARCH IS ONGOING):

 

Abraxane

Analfin

Apokyn

Asotax

Astramorph

Avinza

Biquin

Bris Taxol

Chinidinum

Cin-Quin

DepoDur

Doloral

Domperidone

Duralmor

Duramorph

EPEG

Etopophos

Etopos

Etoposide

Formyxan

Graten

Infumorph

IsonaRif

Kadian

M-Eslon

Mitoxantrone

Mitroxone

Morphine

MOS

Motilium

MS Contin (MSC)

MSIR

Neotalem

Novantrone

Ondansetron

Onxol

Oramorph

Paclisan

Paclitaxel

Praxel

Quinact

Quinaglute

Quinalan

Quinatime

Quinidex

Quinidine

Quinora

Rifadin

Rifamate

Rifampicin

Rifampin

Rifater

Rimactane

RMS

RMS

Rofact

Roxanol

Roxanol

Statex

Taxol

Toposar

Vepesid

VP-Tec

Zofran

 

 

 

See further down the page for more information about MDR1 - multiple drug resistance deficiency and some of the drugs commonly used that can kill your pet! There is now an inexpensive test that can be done to determine if your dog has this deficiency...over 50% of dogs do!

 

~ Always clean up spills immediately…just one lick of antifreeze can kill your pets Use only "safe" antifreeze that says it's non-toxic for pets and wildlife
~ Read the labels of all products to see whether they're non-toxic or not
~ Keep all medications, cleaners, and chemicals in a closed cupboard with a secure fastener well out of the reach of pets and children. Even matches can be toxic!
~ Do not keep poisonous plants in your garden or house. Remember even hanging plants can fall or be jumped onto by cats
~ And most importantly, if your pet seems to be ill, don't medicate it yourself unless under the direction of your veterinarian. Simple medicines, like aspirin, Advil®, or Tylenol®, can be poisonous to pets
~ If your pets get any unknown substance (or known poisonous substance, like paint) on their fur, quickly clean it off. Don't wait for your pets to lick it off; it could be poisonous.
~ Be aware while you're using chemicals and cleaners. Don't let your pet in the room after spraying insecticides. Don't let your pet in your yard after treating for pests or weeds. Don't let your pet in the garage while you work on the car using or replacing fluids, like grease, antifreeze, brake fluid, etc.
~ Just because your house and yard are poison-proof doesn't mean your neighborhood is, so don't let your pets outside to roam unattended. An open garage door or freshly-sprayed yard can mean danger to your unsuspecting and curious pet.
~ Be sure the label of any product you may use on your pets (like flea and tick products and shampoos) specifies that it is safe for that particular species. Many dog products can harm cats and vice versa.
~ Be very careful about feeding human food to your pets. Chocolate, mushrooms & onions can be toxic. And anything too spoiled or moldy for you to eat is too rotten for your pets.

 

Signs of Poisoning:

 

No matter how careful you are, your pets may one day fall victim to poison. If you suspect this, call your veterinarian immediately and report your pet's symptoms. Do not wait to see if the symptoms go away. (In the case of antifreeze poisoning, a dog may act drunk for several hours and then show no symptoms at all for another one to seven hours.)

 

Meanwhile, keep your pet as warm and dry as possible. If you can figure out the source of the poison, take it or a sample with you to the vet. Also take along the poison's container, if possible, since many labels list the antidote.

 

If you suspect poisoning, get to your veterinarian as soon as possible!

 

If you're unsure of the source of the poison, check to see if your pet has been chewing or playing with something questionable like spilled or opened containers of medicine, spoiled food, garbage, etc. An abnormal odor on your pet's breath or body could also signify that your pet has been into something dangerous. Burns or tender areas on the skin or mouth could indicate that your pet has eaten something toxic.

 

ROUTE OF POISON

EXAMPLES

SYMPTOMS

Ingested by mouth

medicines, chemicals-antifreeze, oil, tar, cleaning fluids, polishes, insecticides, weed killer, fertilizers, paints, solvents

stomach and bowel symptoms like cramps, abdominal pain, vomiting and diarrhea; weakness, drooling, slow breathing

Inhaled

fumes from cleaning fluid, gasoline, kerosene, lacquer thinner, airplane glue, automobile or heater exhaust smoke, gas leaks, etc.

coughing, sneezing, shortness of breath, blueness of the lining of the mouth. Difficulty breathing leading to no breathing at all in serious cases

Absorbed by mouth or skin

paint solvents, kerosene, tar, insecticides, strong soaps, acids, and alkalines

redness and irritation on the affected area; possible severe irritation of the eyes and mouth

Injected under the skin

insect bites, snake bites

pain and swelling at the point of contact; general effects on breathing and circulation--the nervous system in general

 

Malicious Poisoning:

 

If you suspect the poisoning was malicious and not accidental, contact your local humane society, animal control agency or police department and provide the necessary information for a full report and investigation. If your pet dies, have an autopsy performed by a veterinarian to determine the exact cause of death. Although this procedure is expensive, it is necessary if charges are brought against a suspected malicious poisoner.

 

Keep your veterinarian's regular and emergency numbers handy!

 

Another excellent site for poisonous plant info is http://www.ansci.cornell.edu/plants

 

Emergency Poison Control Centre Contacts:

 

ASPCA Animal Poison Control Center (USA)
1-888-426-4435

http://www.aspca.org/site/PageServer?pagename=apcc

 

Universal Poison Control Hotline
1-800-222-1222

 

Poison Control Hotline - USA
1-800-548-2423
($30.00/case, credit cards only; follow-up calls no extra charge)

1-900-680-0000
($20.00 for 5 minutes, plus $2.95 each additional minute, $20.00 minimum, no follow ups)

~ ~ ~

Toxicology information

http://www.upei.ca/~toxinfo/news.htm

 

MDR1 - Multiple Drug Resistance Deficiency

 

Molecular biological research is proving that MANY herding breed dogs suffer a genetic flaw called MDR1 - multiple drug resistance deficiency. In sum, the barrier (P-glycoprotein) that protects the brain by transporting a variety of drugs from the brain tissues back into the capillaries is flawed. This is the root cause of the disastrous neurological effects, including death, caused by the ingestion of ivermectin. But, IT'S NOT JUST IVERMECTIN (also known as AVERMECTIN, and the anti-parasitic used in the trade name drug Heartguard and commonly used to treat demodic mange).

 

It's also almost certainly these drugs (alternate names, common usage, and trade names follow the generic name) that cause problems...

  • Metronidazole (diarrhea and giardia)

  • Flagyl; Rozex; Metrogel

  • Butorphanol (pain relief after spay/neuter; cough suppressant and canine flu)

  • Torbutol; Butorphic; Dolorex; Morphasol; Turbogesic

  • Acepromazine (tranquilizer/calming agent and pre-anesthetic) Ace; ACP; Atravet

  • Cyclosporine or Ciclosporin (allergy treatment/immunosuppresant)

  • Sandimmune; Neoral; Cicloral; Gengraf; Restasis

  • Vinblastine and Vincristine (chemotherapy for cancers & leukemia)

  • cancer regimens called CHOP and Stanford V

  • Doxurobicin or Adriamycin or Hydroxyldaunorubicin (chemotherapy for cancers & leukemia)

  • Doxil; cancer regimens called ABVD, CHOP, and FAC

  • Loperamide (diarrhea)

  • Immodium; Lopex; Dimor; Pepto

  • Digoxin (heart ailments)

  • Digitalis (Foxglove) family

Additionally, neurotoxicity in dogs with the MDR1 genetic flaw is suspected to have been caused by:

  • Ondansetron (nausea and vomiting)

  • Zofran; Emeset; Emetron; Ondemet

  • Domperidone (nausea, vomiting, and to stimulate lactation)

  • Motilium

  • Paclitaxel (cancer)

  • Taxol; Abraxane

  • Mitoxantrone (cancer/leukemia)

  • Etoposide (cancer/leukemia)

  • Eposin; Etopophos; Vepeside; VP-16

  • Rifampicin or Rifampin (antibiotic - infections, influenza, pneumonia, staph, meningitis)

  • Rifadin; Rifater; Rimactane; Rifinah; Rimactazid

  • Quinidine (heart)

  • Morphine (pain relief, anesthesia, cough suppressant, anti-diarrheal, shortness of breath)

Drugs that are known to be pumped out of the brain by the protein that the MDR1 gene is responsible for producing but appear to be safely tolerated by dogs with the MDR1 mutation:

  • Cyclosporin (immunosuppressive agent)-While we know that cyclosporin is pumped by P-glycoprotein (the protein encoded by the MDR1 gene), we have not documented any increased sensitivity to this drug in dogs with the MDR1 mutation compared to “normal” dogs. Therefore, we do not recommend altering the dose of cyclosporin for dogs with the MDR1 mutation, but we do recommend therapeutic drug monitoring.

  • Digoxin (cardiac drug)- While we know that digoxin is pumped by P-glycoprotein (the protein encoded by the MDR1 gene), we have not documented any increased sensitivity to this drug in dogs with the MDR1 mutation compared to “normal” dogs.Therefore, we do not recommend altering the dose of digoxin for dogs with the MDR1 mutation, but do recommend therapeutic drug monitoring.

  • Doxycycline (antibacterial drug)- While we know that doxycycline is pumped by P-glycoprotein (the protein encoded by the MDR1 gene), we have not documented any increased sensitivity to this drug in dogs with the MDR1 mutation compared to “normal” dogs.  Therefore, we do not recommend altering the dose of doxycycline for dogs with the MDR1 mutation.

Drugs that may be pumped out by the protein that the MDR1 is responsible for producing, but appear to be safely tolerated by dogs with the MDR1 mutation:

  • Morphine, buprenorphine, fentanyl (opioid analgesics or pain medications)-We suspect that these drugs are pumped by P-glycoprotein (the protein encoded by the MDR1 gene) in dogs because they have been reported to be pumped by P-glycoprotein in people, but we are not aware of any reports of toxicity caused by these drugs in dogs with the MDR1 mutation.We do not have specific dose recommendations for these drugs for dogs with the MDR1 mutation.

The following drugs have been reported to be pumped by P-glycoprotein (the protein encoded by the MDR1) in humans, but there is currently no data  (this can change at any time) stating whether they are or are not pumped by canine P-glycoprotein.Therefore we suggest using caution when administering these drugs to dogs with the MDR1 mutation.

• Domperidone
• Etoposide
• Mitoxantrone
• Ondansetron
• Paclitaxel
• Rifampicin

There are many other drugs that have been shown to be pumped by human P-glycoprotein (the protein encoded by the MDR1 gene), but data is not yet available with regard to their effect in dogs with the MDR1 mutation.

Credit for this information goes to:

Washington State University College of Veterinary Medicine

Veterinary Clinical Pharmacology Laboratory

PO Box 2280

Pullman, WA 99165-2280

(Phone/FAX 509-335-3745)

VCPL@vetmed.wsu.edu

You can learn more about the MDR1 defect and about testing your herding breed dog by going to their website at http://www.vetmed.wsu.edu/depts-VCPL

PLEASE PLEASE PLEASE

Do not leave it up to your vet to know all of this ... YOU must print this out and know about MDR1 ... it IS a matter of life or death.

 

If you have found this page to be of help, please feel free to cross-post a link to this webpage. It's also not just Aussies - affected breeds include Collies, Shetland Sheepdogs (Shelties), Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, Skye Terriers, and a variety of mixed breed dogs.

 

The above information is a compilation of many many different websites, books, email from vets and concerned dog owners. I don’t take credit for anything other than trying to put it all in one document! Please also share any stories you may have on this subject or any other known toxins that I've missed. I try and update this page every time I get new information to share!

 

 

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